In this study, the effect of some of the lithological properties of Iranian granite building stones on the wear of diamond segments of cutting discs was investigated. For this purpose, fourteen samples of widely used commercial Iranian granite stones with different mineralogy compositions were prepared. Mineralogical and petrological studies were carried out on the samples through the study of thin sections, and through this, three important petrological parameters affecting abrasion, including equivalent quartz content, Mohs' overall hardness, and average grain size, were determined for each sample. Then, the stone samples were cut in the laboratory using a cutting machine equipped with a circular disc, and in this way, the amount of segment wear (Ws) was determined for each sample according to the change in its weight before and after cutting. In the next step, with the help of SPSS statistical software, the relationship between petrological parameters and segment wear was investigated through statistical studies of regression analysis. The results showed that the equivalent quartz content has the greatest effect on the amount of segment wear and the linear relationship between this parameter and segment wear is a suitable and logical relationship for estimating the wear of cutting tools during cutting granite construction stones. The coefficient of determination (R2) for this relationship was obtained to be 0.728, which indicates that the proposed relationship is able to predict segment wear with acceptable accuracy.